If only there was a simple answer!
(1) No, we are not alone. Based on all the facts that we are aware of, it is overwhemingly probable that there are other sentient life forms in the universe, and quite probable that there are several of them in our own galaxy.
(2) Yes, we are effectively alone. The balance of probabilities is that, because of galactic distances and timescales, we humans and these other life forms will never become aware of each other. The best reasonable expectation is that, far in the future, we may find the remains of an extinct civilization on some Earth-like planet.