Just done a search on google and it said that sometimes the mississippi river and colorado river do but most sites say that they don't run uphill but flow north...
up the river phrases / idioms
To or in prison, as in They sent him up the river for five years. This phrase originally referred to Sing-Sing Prison, on the Hudson River about 30 miles north of New York City. So used from about 1890 on, it was broadened to apply to any prison by the early 1900s.
I can't remember where i read this but apparently there are only two rivers that at some point actually run uphill one of them was in gloucestershire and the other one in south america somewhere.. the river runs down a hill into a gorge and the momentun takes it uphill over the next hill and it carries on its way..Any ideas as to where this is?