22A Boring problem with making water takes a nastier turn but actually turns out well. (7)
A _ T _ S _ _ _
I thought it was ANTISERA but that clashes with 12D which is as follows:
12D Putting company doctor in at No 1 turns out to rely on on several factors happening together. (11) Pretty sure it's COMBINATION but the A in that word would make the R of ANTISERA an A. Thanks for your help.