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wine and cholesterol

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tucho58 | 14:43 Wed 16th Jun 2004 | Food & Drink
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is it true that wine can lower your cholesterol levels?
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I believe there is some evidence that some of the chemicals in red wine can reduce the absorbtion of cholesterol - however the effect is probably very small and you have to put this context and weigh it up against some of the negative effects of red wine - like extra calories. Recent evidence suggest that the positive effects of alcohol and red wine have been exagerated and there is little evidence that red wine drinkers are healthier than tee-totallers as a result of their wine drinking.
The following extract from ScienceDaily.com:

Scientists at the University of California, Davis, have identified another group of chemicals in red wine that is linked to the ability to lower cholesterol. Called saponins, these glucose-based plant compounds are being found in an increasing number of foods. This is the first time they've been found in wine, says Andrew Waterhouse, Ph.D., Professor of Enology (wine chemistry) at the University of California, Davis. His finding was described today at the 226th national meeting of the American Chemical Society, the world's largest scientific society. For the most part, the so-called French Paradox ' the association between red wine and decreased heart disease ' has been attributed to resveratrol, a compound found in grapes, which acts as an antioxidant. But saponins could be just as important.

The compounds are believed to come from the waxy skin of grapes, which dissolve into the wine during its fermentation process. To better understand their distribution in wine, Waterhouse conducted a preliminary study of six varieties of California wines ' four red and two white ' and compared them on the basis of their saponin content. "Average dietary saponin intake has been estimated at 15 mg, while one glass of red has a total saponin concentration of about half that, making red wine a significant dietary source," the researcher says. In general, Waterhouse found that red wine contains significantly higher saponin levels than white ' about three to ten times as much. Among the red wines tested, red Zinfandel contained the highest levels. Syrah had the second highest, followed by Pinot noir and Cabernet Sauvignon, which had about the same amount. The white varieties tested, Sauvignon blanc and Chardonnay, contained much less. Although Merlot was not analyzed in this study, Waterhouse believes it contains significant amounts of saponins at levels comparable to the other red wines. The study also seems to show a positive correlation between alcohol content and saponin levels. The red Zinfandel tested, which contained the highest level of saponins among all the wines tested, also had the highest level of alcohol, at 16 percent. "We think that alcohol may make the saponins more soluble in wine, but follow up studies are needed," says Waterhouse, who is considered an expert on wine chemistry. According to Waterhouse, red wines contain about the same amount of saponin as they do resveratrol. But while resveratrol is thought to block cholesterol oxidation by its antioxidant action, saponins are believed to work by binding to and preventing the absorption of cholesterol, he says. He also mentioned that saponins are known to affect inflammation pathways, an effect that could have implications in heart disease and cancer, according to published studies
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