"Why do you assume that the universe hangs together in a way that makes explanation possible?"
Because humans are the story-telling animal, it's what we do.
Also, it stands to reason that the universe hangs together in a way that makes explanation possible, eventually. We believe man is in ascent and we believe that, like the last 100 years, the next will contain technology which allows us further insight.
Many of us are just waiting for that small step in technology to unlock further understanding.
There might be unanswerable questions, but I'd say that we're not quite there yet!