I have a book in front of me ... "Memoirs Of The Plague" The main year was 1665. However, the book records in that year, the rate of deaths took off around by May 9th. By mid Sept, 126 parishes infected and 7164 burials recorded due to plague. There were 30,561 plague deaths recorded as early as 1603, then a dramatic fall and then a rise in 1625, then 1636 high again, then 1665 (the big one .. 68,596 died)
Since time immeorial, Bubonic Plague, more commonly known as Black Plague has broken out with greater or lesser severity nearly every generation. The on referenced by AlBags was the " Great Plague of London", lasting, as stated from 1665 to 1666.
Worldwide, the epidemic that ran from the mid-1300's to the early 1400's killed millions in Europe and untold millions more in the Crimea as well as the Far East. In Europe, the death toll was probably near The pandemic followed the Great Famine of 1315-1317 which dramatically affected the health of the population in Europe and contributed to the diseases success. (The population reduction in Europe was estimated to be 30% to as much as 60%.)
Source: Wikipedia's citation of S. Barry and N. Gualde, "The Biggest Epidemics of History")