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What Is The Role Of Cell Cycle Checkpoints, When Do They Occur In The Cell Cycle, And Why Are They Necessary?

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Vortex3607 | 13:37 Mon 04th May 2020 | Science
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Normal cells, however, move through the cell cycle in a regulated way. They use information about their own internal state and cues from the environment around them to decide whether to proceed with cell division. This regulation makes sure that cells don't divide under unfavorable conditions (for instance, when their DNA is damaged, or when there isn't room for more cells in a tissue or organ).

A checkpoint is a stage in the eukaryotic cell cycle at which the cell examines internal and external cues and "decides" whether or not to move forward with division.
There are a number of checkpoints, but the three most important ones are:
• The Gcheckpoint, at the G1/S transition.
• The G2 checkpoint, at the G2 /M transition.
• The spindle checkpoint, at the transition from metaphase to anaphase.

That'll start you off. Now look up these to get the detail you need. There's loads of material and I'm sure you have covered this in class.
The idea is that you learn by finding out and trying to understand and explain it, not just by getting someone to write an answer for you.
Just spotted some typos in my rush to help.

Normal cells (unlike say cancer cells) move through the cell cycle in a regulated way. They use information about their own internal state and cues from the environment around them to decide whether to proceed with cell division. This regulation makes sure that cells don't divide under unfavourable conditions (for instance, when their DNA is damaged, or when there isn't room for more cells in a tissue or organ).

A checkpoint is a stage in the eukaryotic cell cycle at which the cell examines internal and external cues and 'decides' whether or not to move forward with division.
There are a number of checkpoints, but the three most important ones are:
• The G₁ checkpoint, at the G₁/S transition.
• The G₂ checkpoint, at the G₂ /M transition.
• The spindle checkpoint, at the transition from metaphase to anaphase.

That'll start you off. Now look up these to get the detail you need. There's loads of material and I'm sure you have covered this in class.
The idea is that you learn by finding out and trying to understand and explain it, not just by getting someone to write an answer for you.
fiction-factory, I'm failing to understand how you can admit to typos when your both your posts have largely been cut and pasted from the Khan Academy website. Could it be that the subscripts didn't paste as expected?

https://www.khanacademy.org/science/biology/cellular-molecular-biology/stem-cells-and-cancer/a/cell-cycle-checkpoints-article

Surely it would have been better to just provide a link to the Khan Academy website rather than post just a part of the article? The OP could then have done the very thing you suggest ie "Look up these to get the detail you need".

The OP might have found the diagrams beneficial too.
Yes. I was showing that if the OP can just cut and paste questions I can cut and paste (and tweak) answers without me even knowing anything about the topic . The Khan academy is one of many sources but I assume he/she also has books and course notes . Doing one's own research is best in my opinion- exploring helps you learn. hopefully . As a teacher I would rather give someone a suggested reading list and let them find the relevant bits than just give them one article to copy and paste from
Anyway, I've given Vortex tips before on homework/coursework and had no positive acknowledgement so perhaps my help isn't what's needed as maybe he just wants a finished essay from us. Perhaps I'll not bother helping at all if the only feedback I get is someone complaining about my attempt to help
fiction-factory, in no sense was I complaining about your attempt to help; I do find it admirable that many people are prepared to assist others in their questions here on AB.

Given that the OP is not prepared to preface his/her questions with the word "please", nor thank people for replying to the questions, I'd be the first to ask why we should bother. In addition, his/her unwillingness to disclose the nature of the course they are following, whether he/she is at school, at college or at university hardly helps when attempting to provide an answer to the questions. There is also the possibility that the OP's tutor has deliberately composed these questions outside the structure of the course.

Personally, I don't believe for a moment that the OP is not familiar with scouring the internet for the answers required. The Khan Academy wouldn't be the only resouce that he/she would have come across.

Put it this way; no matter which way we look at it, we simply don't know if the OP can interprete the data on any given website or if it is more complex an answer that is required. Internet information is not a "one size fits all" concept as you are aware and the challenge is to find information that is appropriate to the course of study. In view of the fact that we don't know the latter, it follows that any question is difficult to answer. Do we really know if the OP knew and understood all the stuff on the Khan Academy link or was it way beyond his/her understanding? The absence of feedback is striking.

In view of this, I concur that helping the OP is a fruitless exercise. You cannot help those that impede help offered to them and it would seem to me that posting a link and leaving the OP to get on with it is all we can do. It's great that you continue to offer assistance and it may well be that the OP has made use of your advice. However, personally, the uncertainty here is making it difficult to contribute.
fiction-factory, over the years, I've often seen critical criticism when some posters have copy and pasted information from websites without acknowledging the fact and there is some merit in this.

That's why I prefer to post a link. At least then, no one is under the impression that I personally have detailed knowledge of the topic under discussion.

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