hypericin, half life and total body clearence

liney james | 17:35 Fri 25th Apr 2008 | Health & Fitness

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when discussing pharmacology people talk about half life. Ie the amount of time that passes before the blood level of a substance falls by half. How many half-lifes before a substance clears the body completely. ie total body clearance. I'm interested specifically in hypericin. found in St johns wort

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sqad617

How about an uneducated guess...total body clearance time is twice the half life. I am not being facetious because I do not know the answer. However I would have thought that life of it's "pharmacological activity" is the important factor as if it has a half life of so many hours, but is pharmacologically inactive, then "half life" is meaningless.

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