@Old_Geezer
Hardly! The statement that, “God knows best” is not a reasonable response to any question I can think of. According to Biblical scripture, for every good deed that He does, He undoes it ten-fold by His capriciousness and sheer blood-lust.
A murderer does not automatically become a 'nice' person because he remembers his grandmother's birthday and loves his cats – he is still a murderer and should be judged as such. Similarly, when discussing God's credibility as a good and honest entity (and thereby His ability to arbitrate as one who 'knows best'), we should judge Him by His actions. When we do so, we find the God of the Bible sorely wanting. In the words of Richard Dawkins, “... [God is] jealous and proud of it; a petty, unjust, unforgiving control-freak; a vindictive, bloodthirsty ethnic cleanser; a misogynistic, homophobic, racist, infanticidal, genocidal, filicidal, pestilential, megalomaniacal, sadomasochistic, capriciously malevolent bully.”
Given God's recorded actions in the Bible, I don't think that He's qualified to judge what's 'best' for anyone in any situation.