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Guardian 26328

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greencj01 | 09:47 Sat 02nd Aug 2014 | Crosswords
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2d Ye began with this source of annoyance (5)

I have T???N

25a Huge agency makes a hospital suffer a setback (4)

I have ??S?

As always any help gratefully received.
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Thorn?
25a NASA
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Please can someone parse these for me?
NASA - a san(atorium) reversed
A hospital could be a SAN (sanitorium). Backwards (Set back) it becomes NASA
25a SAN - abreviation for sanitorium or hospital
2d. "Thorn" was the old form of writing th as a single letter. It looks like a y - hence "Ye" for "The".

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