The K M Links Game- April Week 3
Quizzes & Puzzles8 mins ago
Trials Start On Anti Malaria Drug To See If It's Effective Against Coved-19
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https:/
Trump will be unbearable now.
Trump will be unbearable now.
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Zacs, the OP has one line relating to Trump - and that is just another pathetic dig. Why Trump is taking it is irrelevant, but we have gone from ‘it’s useless’ - and to quote you ‘it’s not looking promising’ - even though you have been given a link to a promising trial - to ‘maybe it can help’ - which can only be a good thing. The trials are about the drug’s potential as a aid to speedier recovery - not as a ‘cure’ or as ‘prevention’. No one, but no one should be rubbishing any attempt to find something that goes any way whatsoever to help alleviate the effects of this pandemic - however much they hate Trump.
Naomi, stop obfuscating. The link you provided was a trial for a cure or to reduce symptoms, not a preventative. This thread has a link to a trial which seeks to prevent CV19, not cure or lessen the effects.
I never said it’s useless, so to use someone else’s comment in relation to my ‘it’s not looking promising’ is disingenuous and poor debating form.
I haven’t rubbished anything, I’ve merely given the thread some perspective.
I never said it’s useless, so to use someone else’s comment in relation to my ‘it’s not looking promising’ is disingenuous and poor debating form.
I haven’t rubbished anything, I’ve merely given the thread some perspective.
It’s just ‘moved’ I think
Coronavirus: Hydroxychloroquine trial begins in the UK https:/
Coronavirus: Hydroxychloroquine trial begins in the UK https:/
//Funny old world. Got to wonder where their priorities lie.//
their priorities lie in finding and testing drugs that actually work rather than they hope work or a president tells them they work
money is wasted in nailing fanciful presidents foibles
and cd be used for more useful things
( wasted opportunity costs to give it a technical name)
chloroquine will go down in history as an example of money wasted but ( or and ) an example of
that experiment doesnt show it works?
well do one that shows it DOES work !
what we know already is:
it has around 70% inhibition in a test tube and this is NOT translated to useful clinical effect
their priorities lie in finding and testing drugs that actually work rather than they hope work or a president tells them they work
money is wasted in nailing fanciful presidents foibles
and cd be used for more useful things
( wasted opportunity costs to give it a technical name)
chloroquine will go down in history as an example of money wasted but ( or and ) an example of
that experiment doesnt show it works?
well do one that shows it DOES work !
what we know already is:
it has around 70% inhibition in a test tube and this is NOT translated to useful clinical effect
// It does - but the trials so far have been to ascertain whether the drug can assist speedier recovery.//
no - the trials were to see if it was the wonder drug the case reports said it was ( see Trump - lotsa good things coming artta...)
the only thing they ound ( besides it killed more than just saline) was a shortened course
( very short if you re dead)
this is medical short hand for - the drug is a dog for covid
no - the trials were to see if it was the wonder drug the case reports said it was ( see Trump - lotsa good things coming artta...)
the only thing they ound ( besides it killed more than just saline) was a shortened course
( very short if you re dead)
this is medical short hand for - the drug is a dog for covid
Be very wary before taking this drug. I was prescribed Hydroxychlorquine for Rheumatoid Arthritis and after a week or so I developed terrible chest pains. The hospital immediately told me stop taking these as they were effecting my heart which is a common side effect. It was almost 2 weeks after stopping taking these tablets that I was pain free.
sounds about right.
the malaria prophylaxis is once a week ( and that is not because people get bored .... it lasts around a week -chloroquine not the boredom )
and Trump is taking it ( no dose given) every day (*)
on a very technical note:
he terminal elimination half-life is 45-55 days for chloroquine and 59-67 days for its major plasma metabolite desethylchloroquine
jesus that long ! on a par with barbiturates and phenytoin
(*) the Tay the Tay the silvery Tay
it runs thro Dundee every day ! ( Wm Topaz McGonafall)
Is it only me that wonders that on scientifc post such as chloroquine and its safe uses, that there can be 20 consecutive posts that say absolutely nothing?
the malaria prophylaxis is once a week ( and that is not because people get bored .... it lasts around a week -chloroquine not the boredom )
and Trump is taking it ( no dose given) every day (*)
on a very technical note:
he terminal elimination half-life is 45-55 days for chloroquine and 59-67 days for its major plasma metabolite desethylchloroquine
jesus that long ! on a par with barbiturates and phenytoin
(*) the Tay the Tay the silvery Tay
it runs thro Dundee every day ! ( Wm Topaz McGonafall)
Is it only me that wonders that on scientifc post such as chloroquine and its safe uses, that there can be 20 consecutive posts that say absolutely nothing?
As far as I know the drug Trump is taking is two fold in as much as it is believed to be preventative and a ‘cure‘ for mild cases. Both with the right combination of Other drugs of course.
But even if it is just those two things it does is better than anything available SO FAR.
It may be useful as a very cheap first line of defence. It cost something like 10c as opposed to anything else which, because of the big pharmaceutical involved will be very highly priced.
But even if it is just those two things it does is better than anything available SO FAR.
It may be useful as a very cheap first line of defence. It cost something like 10c as opposed to anything else which, because of the big pharmaceutical involved will be very highly priced.
"One recent small open label study observed a synergistic effect from a combination of hydroxychloroquine and azith at clearing viral load in the first week.6 Nevertheless, in a statement on 3 April, International Society of Antimicrobial Chemotherapy, expressed concerns that the article did not “meet the Society’s expected standard, especially relating to the lack of better explanation of the inclusion criteria and the triage of patients to ensure safety”.7
ref 6 is Gaudret - he might have excluded dead people
and the Brazil study
"The primary outcome was a reduction in lethality (that is, death) by at least 50% in the higher dose group and was due to be assessed after 28 days. The study had intended to enrol 440 patients but had only recruited 81 (41 to the higher dose, 40 the lower dose) before the data safety monitoring board terminated the trial. After 13 days, 39% (16/41) patients in the high dose group died compared with 15% (6/40) in the low dose group. The high dose group also experienced more instances of QTc prolongation (18.9% vs 11.1%). Overall, the risk of death was 3.6 times higher in the high dose group, a result that was statistically significant." (and led the trials abandonment}
long technical post - sozza funsters ! - but posted to refute the idea of 'we dont really know what the answer is' [poster looks wistful and puzzled]
It is obvious to me: chloroquine kills more than it cures
ref 6 is Gaudret - he might have excluded dead people
and the Brazil study
"The primary outcome was a reduction in lethality (that is, death) by at least 50% in the higher dose group and was due to be assessed after 28 days. The study had intended to enrol 440 patients but had only recruited 81 (41 to the higher dose, 40 the lower dose) before the data safety monitoring board terminated the trial. After 13 days, 39% (16/41) patients in the high dose group died compared with 15% (6/40) in the low dose group. The high dose group also experienced more instances of QTc prolongation (18.9% vs 11.1%). Overall, the risk of death was 3.6 times higher in the high dose group, a result that was statistically significant." (and led the trials abandonment}
long technical post - sozza funsters ! - but posted to refute the idea of 'we dont really know what the answer is' [poster looks wistful and puzzled]
It is obvious to me: chloroquine kills more than it cures
// Chloroquine and proguanil is available as an over the counter medicine from your pharmacy, so you don't need to see a doctor for a prescription in order to be able to buy it. However, it is important that you make sure that it will protect you from the malaria parasites endemic to the region you are travelling to.//
oh god why dont people find out if a medicine is prescription only ( POM ) before they say it is?
oh god why dont people find out if a medicine is prescription only ( POM ) before they say it is?
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