I've been estranged from my brother for over 2 years now. When we first fell out I was devastated, cried for about a month.
But I felt then and now that there is no going back. He accused me of some awful things, all of which are untrue and totally baseless. I have spent most of my life looking out for him, digging him out of the mire, lending him money (which was never repaid), I even let him live in my house rent-free (more that he just didn't pay any) when I lived away. All of it was thrown back at me.
I will never speak to him again, and I know that some people find that attitude very sad, but I can't have him poisoning my life any more.