big monday crossword, daily express

Please can anyone help? Clue is: the formation of a substance or compound by reaction from simpler materials. 9 letters. I have S - - T - - S - S. Many thanks to anyone who has better brains than me. T.
00:26 Tue 01st May 2012
 
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synthesis
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Bless you Paddywak. Many thanks. T

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